The ai: h..r in a, attempt to evaluate hem.od;na?nic cihang:´s !´ the clinical stages of Korean hemorrha;gic fever measured plasma volume, cardiac output and effective renal plasma flow utilizing radicisotc es during various phases,ef the disease. Cardiac output was measured by radiocardiography with exte.nal monitoring method using RIHSA. Effective renal plasma fl:;w was obtained from blood clearance curve drawn by external monitoring after raiiehippuran injection according to the nieth;d disc:ibec´ by The study was carried cut in thirty-eight cas_s C,_ an her o.rhagic fever and th:; f.alo:ving ccilck signs v; ere obtai red.
l, ii?S .fl voknr.e :Vas increased in the patients dli_i_ag the el:guric-and
ii per e.aa ve-ci_;re*_´c ph", as.s, vwhil_´ it was normal in the patients duriiig t!:--n o-nactensive-diuretic phase.
-) ? !r A la index: was increased i n the patients 3uring the oliguric phr se and was slightly Lecreas_d in tae´ p al-den´S at the hypartensive diuretic p´_a. ?: was normal iri t e other phases.
3. Total peripheral resistance wr_ s increased in t he hj pert naive patients during d:; r:tic phase, while it was normal in the rest of phases.
4. Effective renal plasma flour w s significantly reduced in the patients during the cliguric and diuretic phases as well as at one month after the olig.iric onset. There was no significant difference between the cliguric and the early diuretic phases. Ten,! plasma flow in the groap of patients at one month after the oliguric onset was about 45% of tie normal, however, it returned to normal level at sip: months after the onset.
5. Clinical syna.´o:cc of relative hyp;.rVrlc"._is ´. iS :´ s ve3 in S-me patients duri_r j the olig´Sric phL´s_ or hypertensive diuretic phase. `1-ndi ngs ere high cardiac output and norm---I o relatively increased p°riph:.r l c::ses. Ref tive!y inc ca.^-. circulating blood ,-t´.._- de_.,.:s d effective .s s: ;"_s:_.. to´ thenech_nis_~::f relative hyper:., l
:?r´´´_ac the a_Leraticn i´etu ne..l ´g I.-´e s`t:.ge of the dii etic phase.
; = 1 r_
while rear.-I ier.iodynalnk changes were s´.:- _, -the atie:- - -a set.
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